The 2019 runner-up will begin his bid for a first Grand Slam trophy against Federico Delbonis, closing Day 2 play under the lights on Arthur Ashe Stadium. Medvedev, this year’s third seed, will hope to build on his run to the Western & Southern Open quarter-finals last week.
The Russian No. 1 did not drop a set en route to the last eight at the ATP Masters 1000 event, before a three-set loss to Roberto Bautista Agut. Medvedev was aiming to retain the trophy he had won in 2019, prior to his run to the US Open final.
Medvedev will face Delbonis for the first time. Delbonis has recent experience of playing against the biggest names on the most iconic courts in the sport. At this year’s Australian Open, the Argentine saved 17 of 20 break points in a two-hour, 30-minute loss to Rafael Nadal on Rod Laver Arena.
Murray will look to improve on his 45-12 US Open record after an encouraging week at the Western & Southern Open. Following a first-round win against Frances Tiafoe at the Masters 1000 tournament, Murray outlasted World No. 7 Alexander Zverev in three sets to earn his first Top 10 victory since 2017 Roland Garros.
Second seed Dominic Thiem will begin his US Open campaign against Spain’s Jaume Munar on Louis Armstrong Stadium. This year’s Australian Open runner-up is seeking his first victory since beating Munar at the Rio Open presented by Claro in February. In his first match since the resumption of the ATP Tour last week, Thiem earned just three games in an opening-round loss to Filip Krajinovic at the Western & Southern Open.
Thiem owns a 3-0 ATP Head2Head record against 2018 Next Gen ATP Finals semi-finalist Munar. Each of the pair’s three encounters have been contested on clay, with Munar taking his only set against the Austrian in their most recent clash in Rio de Janeiro.
Grigor Dimitrov faces Tommy Paul in the final match on Louis Armstrong Stadium. The 14th seed advanced to his third Grand Slam semi-final at the event last year, beating Roger Federer in five sets to reach the last four.
If the 14th seed is to enjoy another deep run in New York, he will need to record his first victory against Paul. At this year’s Australian Open, the 23-year-old American stunned Dimitrov in a fifth-set tie-break to reach the third round of a Grand Slam for the first time.
Matteo Berrettini, who also reached the 2019 semi-finals, opens his US Open campaign on Court 17 against Go Soeda of Japan. The sixth seed contested one of the matches of the tournament last year, beating Gael Monfils in a final-set tie-break to reach his first Grand Slam semi-final.
Canadians Milos Raonic and Felix Auger-Aliassime will also feature on Court 17. Raonic, who advanced to his fourth Masters 1000 final at the Western & Southern Open, meets Leonardo Mayer for a spot in the second round. Auger-Aliassime faces Thiago Monteiro of Brazil for the first time.
Western & Southern Open semi-finalist Bautista Agut will hope to carry his form through to his first ATP Head2Head meeting against two-time Australian Open quarter-finalist Sandgren, while Sinner is seeking his first tour-level victory since February against Khachanov. Khachanov advanced to the Western & Southern Open third round last week.